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Clozapine and Polycythemia Rubra Vera: A Rare Side Effect or a Separate Medical Condition? A Case Report

Date: 13 June 2017

MJP Online Code: MJP-02-07-16

Section: Case Report

Author: Tan HPJ

Institution: Hospital Sentosa, Kuching, Sarawak, Malaysia

Keywords: Clozapine, Polycythemia Rubra Vera, Blood Dyscrasia

Abstract: This article highlights the case of a 44-year old Malay man who is diagnosed as having treatment resistant schizophrenia on Clozapine, which then developed Polycythemia Rubra Vera (PRV). It is known that a major side effect for Clozapine is of agranulocytosis, that is a potentially fatal side effect. However, there have been reported disturbances of other hematological parameters, which result in other abnormalities including leucopenia, leucocytosis, thrombocytopenia, thrombocytosis and eosinophilia. Could this case be a pure medical condition of PRV or is there a relation to the effects of Clozapine? In this paper, the aim is to report a case of blood dyscrasia in a 44-year old male who developed Polycythemia Rubra Vera a year after he was observed to have abnormal full blood count results.

To read the full paper please login to MPA's website via the member login or visit MPA's Malaysian Journal of Psychiatry (MJP) e-Journal website at www.mjpsychiatry.org


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